Drugs Having Clinically Important Interactions with ABILIFY MAINTENA: See Table 7.
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Drugs Having No Clinically Important Interactions with ABILIFY MAINTENA: Based on pharmacokinetic studies with oral aripiprazole, no dosage adjustment of ABILIFY MAINTENA is required when administered concomitantly with famotidine, valproate, lithium, lorazepam [see PHARMACOLOGY: Pharmacokinetics under Actions].
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin), or CYP3A4 (e.g., dextromethorphan) when co-administered with ABILIFY MAINTENA. Additionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when co-administered with ABILIFY MAINTENA. [See PHARMACOLOGY: Pharmacokinetics under Actions.]